Antonyms for the word "setting at ease" are words that suggest discomfort or anxiety. These words include anxious, uneasy, restless, tense, nervous, uncomfortable, and worried. When we don't feel at ease, we may be experiencing negative emotions like fear, apprehension, or tension. These feelings can be caused by various situations, such as facing an exam, being in a new environment, meeting new people, or being in a conversation that causes stress. It's essential to understand antonyms for the word "setting at ease" to help us identify negative emotions and take steps towards overcoming them. We can do this through relaxation techniques, talking to someone we trust, or seeking professional help.