The concept of "make holy" implies the act of sanctification or purification, but there are many opposite antonyms to this process. Some examples of antonyms for the term "make holy" include defile, profane, desecrate, secularize, contaminate, pollute, and corrupt. These words describe actions that work against the purity or holiness of a person or object. The antonyms illustrate the opposite meaning, in which individuals or objects are degraded, tainted, or ruined. The opposite of sanctification, which is profanation, is typically caused by human actions - such as neglect or disrespect - that result in a loss of purity or sacredness.