"Bighted" is a word that refers to being affected by a disease, condition or curse, leading to a state of devastation or ruin. Some synonyms for this word include "blighted", "plagued", "afflicted", "damaged", "ruined", "spoiled", "cursed", "doomed", "jinxed", "ill-fated", "unlucky" and "catastrophic". Each of these words conveys a sense of negative impact on a person, place or thing, usually as a result of factors that are beyond anyone's control. Whether it's an individual, a community or an entire ecosystem that has been "bighted", these synonyms all suggest a bleak and dire situation that requires some form of intervention to rectify.